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The history of psychedelic substance use, modern research efforts, and their potential clinical applications addressing current treatment resistant mental health disorders evolved through an intriguing and complexly interwoven story linking ancient cultures, modern discovery, pop cultural movements, national and international politics, and well-intentioned laws with unintended consequences. In the context of this history, this commentary discusses the 21st century resurgence of psychedelic drug assisted psychotherapeutic research, the challenges imposed by the United States Controlled Substance Act (US CSA), and the potential for development of medicinal products for the treatment of persisting mental health disorders.
The unrelenting persistence of behavioral disorders, for which those who are afflicted and refractory to current evidenced based therapies, reveal a powerful incentivizing force for advancing new medicinally assisted psychotherapeutic treatments. On the other hand, we enter the 21st century humbled by the daunting challenge of developing medicines for central nervous system (CNS) disorders in response to the failure of so many seemingly promising medicines that emerged from years of clinical trials, billions of US dollars invested, with benefit to risk profiles which at the time, were acceptable to regulatory agencies in the US and globally (Hyman, 2012; Pangalos et al., 2007; Pankevich et al., 2014). With these considerations in mind, the present commentary is not postured as advocacy for a simple or certain solution to the challenges posed by mental health disorders or “brain diseases.” Nonetheless, it suggests that pressing public health challenges involving behavioral disorders may be addressed in part by recent advances in neuropharmacology, on the effects, mechanisms of action, and potential clinical applications of psychedelic drugs discussed in this special issue of Neuropharmacology. Together, these advances support our conclusion that increased scientific investigation of psychedelic substances for potential clinical application merits serious consideration among the many other efforts that are vigorously being pursued to address mental health illnesses that continue to be so pervasive in the United States and globally.
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Is DMT legal in Washington. Washington’s drug laws are relatively progressive. This may be obvious to some, as the Evergreen State was the first to legalize recreational marijuana. However, getting to know their current laws can prove challenging, as authorities continue to make changes monthly. This article will summarize all the laws regulating magic mushrooms, …
Is DMT legal in Oakland. In Oakland, It is not legal to buy or sell but ownership and usage of ALL NATURALLY occurring psychedelics is now decriminalized. So if you possess a source of naturally occurring DMT in the form of root or tree bark and are caught with it, nothing happens. If you were …
Psychedelic Drug Laws in Colorado. Colorado is considered one of the more “relaxed” states when it comes to psychedelics and plant-based substances. It was the second state to legalize marijuana for recreational use (just four days behind Washington) and the home of the first US city to decriminalize the use of magic mushrooms (Denver). Here, …
Are Psychedelics Legal In Nevada? Magic mushrooms are one of the most widely-consumed psychedelics in the world, both medicinally and recreationally. Unfortunately, this substance is only legal in countries like Mexico, Peru, and Costa Rica for cultural reasons. Below you will learn about the legality of psilocybin and other psychedelics in Nevada, USA. Are Magic …
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Where Are Magic Mushrooms Legal? State-By-State Guide In 1968, the USA officially banned psilocybin. It’s remained illegal ever since, but thanks to the effort of activists and researchers’ these laws could change very soon. An increasing number of studies support the medicinal use of magic mushrooms and their active ingredient, psilocybin. Below, we will take a look …
Where Are Magic Mushrooms Legal? State-By-State Guide Read More »
How and where can I buy DMT Online Discreetly? What Is DMT? How and where can I buy DMT Online Discreetly?. According to the DEA, the drug N, N-dimethyltryptamine, or DMT, is a potent hallucinogenic drug that has been used for centuries by a number of different groups in South America in their religious services. The National …
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